Sunday, July 30, 2023

Synthetic life


"Ye are gods, and all of you are children of the Most High." Psalm 82:6


A team of scientists at the University of Cambridge announced that they had created synthetic human embryos that were able to develop to the gastrulation stage, which is the stage at which embryos begin to form their organs.
These are just a few of the milestones in the development of synthetic human embryos. As research in this area continues, it is likely that we will see even more advances in the years to come.

Here are some of the ethical concerns that have been raised about synthetic human embryos:
  • The potential for abuse: Some people are concerned that synthetic human embryos could be used for unethical purposes, such as creating designer babies or conducting experiments that would harm the embryos.
  • The moral status of embryos: There is no consensus on the moral status of embryos, and some people believe that it is wrong to create or use synthetic embryos.
  • The safety of synthetic embryos: There is some concern that synthetic embryos could pose a risk to human health, either because they could be used to transmit diseases or because they could cause complications during pregnancy.
It is important to note that these are just some of the ethical concerns that have been raised about synthetic human embryos. There are many other potential ethical issues that could arise as research in this area continues.

Synthetic structures in the world, similar to human embryos, can be created from stem cells, bypassing the need for eggs and sperm: stem cells are first collected from a source, such as adult tissue or an embryo. The stem cells are then reprogrammed to become pluripotent, which means they can differentiate into any type of cell in the body. (The pluripotent cells are then grown in an environment that encourages them to develop into structures similar to human embryos.)

The human embryo-like structures could then be used to study human development or to create new medical treatments.

This technology is still in its early stages of development, but it has the potential to revolutionize the way we treat infertility, disease and even aging.

Here are some of the possible applications of synthetic structures in the world, similar to human embryos:

  • Treatment of infertility: Human embryo-like structures can be used to create embryos in the laboratory that can be implanted in a woman's uterus to generate a pregnancy. This may be an option for couples who are infertile due to problems with their eggs or sperm.
  • Development of new medical treatments: Human embryo-like structures can be used to study human development and identify new treatments for diseases. For example, human embryo-like structures could be used to study the development of heart disease, cancer and diabetes.
  • Preventing Aging: Human embryo-like structures can be used to study the aging process and identify new ways to prevent or delay aging.
Note that the world's synthetic structures, similar to human embryos, raise some ethical concerns. For example, some people are concerned that this technology could be used to create "designer babies" who are designed to have certain physical or intellectual characteristics. Also, some people are concerned that this technology could be used to create human embryos that won't implant in the womb and will be discarded. It is important to carefully weigh the potential benefits and risks of this technology before deploying it in clinical applications.

Synthetic human embryo-like structures from stem cells, bypassing the need for eggs and sperm, are a new and rapidly developing field of research. These structures are created by taking pluripotent stem cells, which can differentiate into any type of cell in the body, and coaxing them to self-organize into structures that resemble early human embryos.


There are several potential benefits to using synthetic human embryo-like structures for research:

First, they can be used to study the early stages of human development in a more controlled environment than is possible with real embryos. This could help us to better understand how human embryos develop and how defects can arise.

Second, synthetic human embryo-like structures can be used to test new drugs and treatments for diseases that affect early development. This could potentially lead to new treatments for conditions such as infertility, miscarriage, and birth defects.

Third, synthetic human embryo-like structures could be used to create new types of stem cells. These stem cells could be used to repair damaged tissues or organs, or to create new organs for transplantation.


However, there are also some ethical concerns associated with the use of synthetic human embryo-like structures. Some people believe that it is wrong to create or use structures that resemble human embryos, even if they do not contain any genetic material from a real embryo.

Others are concerned that synthetic human embryo-like structures could be used to create "designer babies" that are designed to have certain characteristics. This could lead to a society where people are stratified based on their genetic makeup, which could have serious social and ethical consequences.

Overall, the use of synthetic human embryo-like structures is a promising new area of research with the potential to benefit human health in many ways. However, it is important to carefully consider the ethical implications of this research before it is widely adopted.

As research in this area continues, it is likely that we will see even more advances in the years to come. It is possible that synthetic human embryo-like structures could become a routine tool for research in the future, and they could even have the potential to be used for clinical applications such as treatment of infertility or birth defects.

“I just wish to stress that they are not human embryos,” Zernicka-Goetz said. “They are embryo models, but they are very exciting because they are very looking similar to human embryos and very important path towards discovery of why so many pregnancies fail, as the majority of the pregnancies fail around the time of the development at which we build these embryo-like structures.” (CNN)


Prof Magdalena Żernicka-Goetz

Magdalena Żernicka-Goetz is a Polish-British developmental biologist. She is Professor of Mammalian Development and Stem Cell Biology in the Department of Physiology, Development and Neuroscience and Fellow of Sidney Sussex College, Cambridge.

Żernicka-Goetz received her Master of Science degree (summa cum laude) in developmental biology (1988) and her PhD degree in the developmental biology of mammals (1993) from the University of Warsaw, with one year (1990–91) spent at the University of Oxford. She then moved to the United States to do her postdoctoral research at the University of California, San Francisco, where she worked with Dr. Eric S. Lander.

In 1997, Żernicka-Goetz returned to the United Kingdom to join the faculty of the University of Cambridge. Her research has focused on understanding the early stages of mammalian development, with a particular interest in the role of stem cells in this process. She has made significant contributions to our understanding of how stem cells self-organize to form embryos, and her work has implications for the development of new treatments for infertility and birth defects.

Żernicka-Goetz is a Fellow of the Royal Society (FRS) and a member of the European Molecular Biology Organization (EMBO). She has received numerous awards for her research, including the Wellcome Trust Senior Investigator Award, the European Research Council Advanced Grant, and the Louis-Jeantet Prize.

She is a passionate advocate for science education and public engagement. She is a regular contributor to the media, and she has written several popular science books, including "The Dance of Life: Symmetry, Cells and How We Become Human".

Żernicka-Goetz is a leading figure in the field of developmental biology. 

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